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Although judicious use of tyrosine kinase inhibitors that target bcrabl constitutes an effective strategy for the control of chronic myeloid leukemia cml, drug resistance is observed due to kinase domain mutations, among which a major one is bcrablt315i.

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Ncbi 25759 Mim 605217 Hgnc 29869 Ensembl Ensg6 Dbsnp 25759 Clinvar 25759 Tcga Ensg6 Cosmic Shc2.

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